About

Biological Systems Engineering Lab

  • Biological Systems Engineering Lab
  • Research Groups
  • BIO-REMOTE
  • BIO-REMOTE
  • Biweekly lab seminar 1
  • Biweekly lab seminar 2
  • Biweekly lab seminar 3
  • Biweekly lab seminar 4
  • Biweekly lab seminar 5
  • Biological Systems Engineering Lab
  • Research Groups
  • BIO-REMOTE
  • BIO-REMOTE
  • Medical engineering group Seminar 1
  • Medical engineering group Seminar 2
  • Medical engineering group Seminar 3
  • Medical engineering group Seminar 4
  • Kansei brain group Seminar 1
  • Kansei brain group Seminar 2
  • Kansei brain group Seminar 3
  • Kansei brain group Seminar 4
  • Human modeling group Seminar 1
  • Human modeling group Seminar 2
  • Human modeling group Seminar 3
  • Human modeling group Seminar 4
  • Biological signal analysis group Seminar 1
  • Biological signal analysis group Seminar 2
  • Biological signal analysis group Seminar 3
  • Biological signal analysis group Seminar 4
  • Biological Systems Engineering Lab
  • Research Groups
  • BIO-REMOTE
  • BIO-REMOTE
  • Biweekly lab meeting 4
  • Biweekly lab meeting 4
  • Biweekly lab meeting 4
  • Biweekly lab meeting 4
  • Biweekly lab meeting 4
  • Biweekly lab meeting 4
  • Biweekly lab meeting 4
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Living organisms developed in nature through the evolution process are equipped with supremely skilled and sophisticated biological functions that cannot be realized with current engineering techniques. Analysis of these mechanisms may lead to not only elucidation of biological functions but also development of a wide variety of novel engineering systems.

From the viewpoint of a scientist approaching the secrets of living organisms and from that of an engineer developing machinery useful for human kind, the members of Biological Systems Engineering laboratory work on a wide variety of projects to analyze the characteristics of biological functions from theoretical and experimental approaches employing engineering techniques aiming to find new principles peculiar to biological systems, and develop novel medical/welfare apparatuses and industrial devices by applying the elucidated principles.

Through such research activities, the students can learn in-depth knowledge about biological systems based on electricity, electronics, systems and information engineering foundation allowing themselves to become creative engineers capable of seeking a new principle and expanding it into new fields.

Features

  • Biweekly lab seminar 1
  • Biweekly lab seminar 2
  • Biweekly lab seminar 3
  • Biweekly lab seminar 4
  • Biweekly lab seminar 5

Biweekly lab seminar

As of 2017, total of 42 senior undergraduate students, graduate students and doctoral students are working in the lab. The students are involved in either of the four research groups according to their research projects, which are ME group (Medical engineering group), Kansei brain group (Former A-life Group), EMG Group (Biological signal analysis group), and Human modeling group (Former Biological Motion Analysis Group). Since the group each consists of students from all grades, the student can acquire the necessary knowledge and skills required fora researcher and a member of societyas well throughthe lab. activities that the senior teaches the junior and the juniors help the seniors. Since the number of students is quite large compared to the usual laboratory, the lab. is managed as the followings.

  • Medical engineering group Seminar 1
  • Medical engineering group Seminar 2
  • Medical engineering group Seminar 3
  • Medical engineering group Seminar 4
  • Kansei brain group Seminar 1
  • Kansei brain group Seminar 2
  • Kansei brain group Seminar 3
  • Kansei brain group Seminar 4
  • Human modeling group Seminar 1
  • Human modeling group Seminar 2
  • Human modeling group Seminar 3
  • Human modeling group Seminar 4
  • Biological signal analysis group Seminar 1
  • Biological signal analysis group Seminar 2
  • Biological signal analysis group Seminar 3
  • Biological signal analysis group Seminar 4

Group seminars

Regarding education, we divide the students into four research groups corresponding to each research project, andconduct education and research activities on a group-by-group basis. We promote collaboration between graduate students and undergraduate students by organize each research group with students from all grades as much as possible. We alsoencourage the students to manage the group and teach each other by their own by assigning group leaders and sub leaders.In this way, we intend not only to increase autonomy of research activities but also to cultivate leadership mindset and skills enablingsupervision of their future community.

Specific education and research guidance is conducted throughout the all-member seminar (held once a week) participated by all members including facilities and students, the group seminars (held once a week) in each group, graduation theses and master thesis presentations (held twice a year),and the workshops for respective research projects. Especially, the workshops held on a regular basis, whichis a meeting that invites the collaborators from various department, universities, public research institutions and companies, can provide valuable chances for the students tocommunicate with researchers outside the laboratory.

  • Biweekly lab meeting 4
  • Biweekly lab meeting 4
  • Biweekly lab meeting 4
  • Biweekly lab meeting 4
  • Biweekly lab meeting 4
  • Biweekly lab meeting 4
  • Biweekly lab meeting 4
  • Biweekly lab meeting

    Students' rotating representatives participate to the staff meeting biweekly held for entire laboratory management so that they can have opportunities to acquire knowledge and experience about organization management.In addition, we always try to revitalize our laboratorythrough conducting research evaluation questionnaire between students, issue of e-mail magazine (once a week), management of lab. homepage, encouragement of presentation at academic conferences both in Japan and abroad, active participation in various exhibitions, and holding laboratory tours for visitors.

    Five research themes

    There are still a lot of unknown functions and mechanisms hidden in the biological system. If we can elucidate and utilize them from engineering standpoint,then there is a possibility of creating new technologies to carve out the future of the 21st century. The Biological Systems Engineering Laboratory categorizes the broad research field of biological systems into five major research themes in order to explore specific research projects under each theme, and further functionally coordinate and fuse each theme to create novel research fields.

    Research Theme 1Biological signal analysis and its application to human interfaces

    We develop novel signal processing algorithms that enablethe interpretation of human motions, intentions, and physiological/psychological states contained in biological signals, such as myoelectric signals, electroencephalograms, and electrocardiograms, as well as create robotic interfaces and medical welfare equipment.

    Specific Research Projects

    • Biological signal discrimination by the neural networks
    • Skill assistance by work model
    • Development of myoelectric arms/human assist robots
    • Development of cybernetic interface Bio-remote/Bio-pointer/Bio-vocoder/Amusement interface/Bio-music interface/EEG interface/Cybernetic robot interface: CHRIS/Cybernetic glove box/Cybernetic rehabilitation aid

    Research Theme 2Biomechanical analysis and its application to human-machine system design

    We model human sensory/motor functions from electrical and electronicperspectives based on experimentally measured data, and develop novel movement support systems and next-generation automobile control systems by incorporating modeled human characteristics.

    Specific Research Projects

    • Measurement/modeling of human hand/joint impedance
    • Analysis of human impedance perception characteristics
    • Analysis of human hand trajectory generation mechanism
    • Manipulability analysis
    • Impedance matching of human and machine
    • Development of virtual sports rehabilitation aid
    • Human-automotive system analysis

    Research Theme 3Statistical structure of neural networks based on novel machine learning algorithms

    We propose new machine learning algorithms and neural networks based on probabilistic statistical theory and applythese to the development oflearning and control technologiesfor robots, medical welfare equipment, and medical data classificationtechnology.

    Specific Research Projects

    • Log-linearized Gaussian Mixture Network(LLGMN)
    • Recurrent LLGMN
    • Hierarchical LLGMN
    • Reduced-dimensional LLGMN
    • Deep probabilistic neural networks
    • Terminal learning algorithm
    • Unsupervised learning algorithm
    • Biomimetic control through machine learning
    • Neural chips

    Research Theme 4Brain function/neural network modeling and artificial life models

    Focusing on functions such as locomotion generation, sensation, perception, learning, and judgment, we model brain functions from an engineering viewpoint using artificial neural networks. Ultimately, we aim to model and analyze higher brain functions, especially social brain functions that understand the minds of others and live harmoniously, and Kansei that involves nonverbal, unconscious, and intuitive sensibilities. We also develop artificial life form models based on biological knowledge using the constructed brain models.

    Specific Research Projects

    • Mouseolfactory model and odor classification system
    • Modeling the human olfactory system and estimation of brain function andKansei
    • Bioelectrical signal measurement and emotion estimation of small fishes
    • Dynamical model analysis of small fishes and muscle activity/neural activity estimation
    • Biomimetic control ofCaenorhabditis elegans robot
    • Virtual bacteria
    • Virtual Paramecium
    • Virtual Caenorhabditis elegans

    Research Theme 5Biometric information mining technology and medical support systems

    We are engaged in the research and development of novel medical support systems and medical devices through medicine-engineering collaborations by utilizing electric and electronic systems and information engineering technologies, such as biomechanical analysis technology, biological signal analysis technology, machine learning technology, and biological simulation technology that were developed in the Biological Systems Engineering laboratory.

    Specific Research Projects

    • Measurement/modeling of arterial impedance characteristics
    • Vascular viscoelastic index estimation using ultrasonic image
    • Non-invasive biological signal measurement and continuous blood pressure measurement
    • Autonomic nerve activity evaluation and surgical operation support system
    • Finger-tapping motion analysis and higher brain function evaluation
    • Diagnosis support system for Parkinson's disease
    • Newborn infant motion evaluation
    • Quantitative pain evaluation and fMRI measurement

    Research groups

    Medical engineering group

    Medical engineering group

    Adopting the latest engineering technology is requisite for the medical research of the 21st century. Medical engineering is a field in which medical and engineering are integrated, and medical engineering (ME) group has been engaged in biomechanical analysis technology, biological signal analysis technology, machine learning technology, biological simulation technology to develop novel medical support systems and medical devices by exploiting electric and electronic information system technology.

    Fundamental Research

    • Vascular inpedance characteristics measurement and modeling
    • Vascular viscoelatic index estimation using ultrasonographic image
    • Non-ivasive biological signal measurement and blood pressure measurement

    Applied Research

    • Autonomic nerve activity evaluation and surgical operation support system
    • Finger tap motion analysis and higher brain function evaluation
    • Development of diagnostic support system for Parkinson's disease
    • Development of a newborn infant motor evaluation method
    • Development of pain quantitative evaluation method and fMRI measurement

    Kansei brain group

    Kansei brain group

    Focusing on functions such as locomotion, sensation, perception, learning and judgment of the brain, Kansei Brain group tries to model and simulate its function by artificial neural network models from the viewpoint of engineering. This group ultimately aims to model and clarify nonverbal, unconscious, and intuitive ""Kansei", as well as the social brain functions that enable us to understand and cooperate with others. Employing the constracted brain models, we also develop artificial life models based on biological insights.

    Fundamental Research

    • Olfactory model of mice and odor identification system
    • Modeling human olfactory system and estimating cerebral function and Kansei
    • Bioelectrical signal measurement and emotion estimation of a small fish
    • Dynamical model analysis for estimating the muscle activities and neural activity of a small fish

    Applied Research

    • Biomimetic control of Caenorhabditis elegans robot
    • Development of virtual bacteria
    • Development of virtual paramecium
    • Development of virtual Caenorhabditis elegans

    Human modeling group

    Human modeling group

    In the human modeling group, through technologies that extend human exercise and sensation, we aim to realize an excellent human mechanical system. In order to enjoy the daily life even at the age, we think that it is important to maintain the feeling that I am moving my body freely by myself, and feel a sense of feeling various things by myself.

    Fundamental Research

    • Human motion impedance characteristics
    • Human impedance perception
    • Operability analysis and impedance adjustment
    • Human hand trajectory generation mechanism

    Applied Research

    • Impedance training
    • Virtual sports training
    • Sports motion analysis
    • Analysis of automobile operability
    • Development of a driving seat design support system
    • Powered suit without electricity: Unplugged powered suit
    • Sensorimotor-enhancing suit (SEnS)
    • Prediction of tactile sensibility from touch surface changes

    Biological signal analysis group

    Biological signal analysis group

    When trying to produce muscle force, electrical impulses are transmitted from the brain through nerves, and the muscles discharge electricity. The measured electrical signal is called an electromyogram (EMG). There are various bioelectric signals that can be measured from the human body, such as electroencephalograms and electrocardiograms. The biological signal analysis group is engaged in the development of proprietary signal processing algorithms to identify motion intentions and the physiological/psychological states of human beings contained in their measured bioelectric signals. In addition, we have proposed novel robot interfaces and medical welfare devices using biosignals as input.

    Fundamental Research

    • Development of new probability neural network: Log-linearized Gaussian Mixture Network (LLGMN), Recurrent LLGMN, Hierarchical LLGMN, Reduced-dimensional LLGMN, Deep probability neural network
    • Development of terminal learning algorithm
    • Biosignal classification using neural networks
    • Skill assistance using a work model

    Applied Research

    • Development of cybernetic interface: Bio-Remote, Bio-Pointer, Bio-Vocoder, Bio-Music, electroencephalogram interface, cybernetic robot interface (CHRIS), cybernetics glove box, cybernetic rehabilitation aid
    • Development of multi-functional myoelectric prosthesis
    • Learning-type biomimetic control

    Publications

    Our research results have been published in scientific journals, books, conference proceedings, patent, etc.. The numbers of publications the lab produced are shown as follows
    (as of October 24, 2020):

    Latest papers

    Predictors of stroke outcome extracted from multivariate linear discriminant analysis or neural network analysis

    Tomohisa Nezu, Naohisa Hosomi, Kazumasa Yoshimura, Hiroyuki Naito, Shiro Aoki, Yuko Morimoto, Masato Kinboshi, Takeshi Yoshida, Yuji Shiga, Naoto Kinoshita, Akira Furui, Genta Tabuchi, Hiroki Ueno, Toshio Tsuji, and Hirofumi Maruyama
    Journal of Atherosclerosis and Thrombosis (accepted, SCI, IF=3.876)

    Longitudinal Assessment of U-shaped and Inverted U-shaped Developmental Changes in the Spontaneous Movements of Infants via Markerless Video Analysis

    Naoki Kinoshita, Akira Furui, Zu Soh, Hideaki Hayashi, Taro Shibanoki, Hiroki Mori, Koji Shimatani, Yasuko Funabiki, and Toshio Tsuji
    Scientific Reports, volume 10, Article number: 16827, doi.org/10.1038/s41598-020-74006-y, Published online: 08 October 2020. (SCI, IF=3.998)
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    Targeted central nervous system irradiation of Caenorhabditis elegans induces a limited effect on motility

    Michiyo Suzuki, Zu Soh, Hiroki Yamashita, Toshio Tsuji, and Tomoo Funayama
    Biology, volume 9, issue 9, 289, DOI 10.3390/biology9090289, Published: 14 September 2020 (SCI, IF=3.796)
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    Recurrent Probabilistic Neural Network-based Short-term Prediction for Acute Hypotension and Ventricular Fibrillation

    Toshio Tsuji, Tomonori Nobukawa, Akihisa Mito, Harutoyo Hirano, Zu Soh, Ryota Inokuchi, Etsunori Fujita, Yumi Ogura, Shigehiko Kaneko, Ryuji Nakamura, Noboru Saeki, Masashi Kawamoto, and Masao Yoshizumi
    Scientific Reports, volume 10, Article number: 11970, doi:doi.org/10.1038/s41598-020-68627-6, Published online: 20 July 2020. (SCI, IF=4.011)
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    Non-Gaussianity Detection of EEG Signals Based on a Multivariate Scale Mixture Model for Diagnosis of Epileptic Seizures

    Akira Furui, Ryota Onishi, Akihito Takeuchi, Tomoyuki Akiyama, and Toshio Tsuji
    IEEE Transactions on Biomedical Engineering, Digital Object Identifier: 10.1109/TBME.2020.3006246, Date of publication: 01 July 2020 (SCI, IF = 4.424)
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    Video-based Evaluation of Infant Crawling toward Quantitative Assessment of Motor Development

    Katsuaki Kawashima, Yasuko Funabiki, Shino Ogawa, Hideaki Hayashi, Zu Soh, Akira Furui, Ayumi Sato, Taiko Shiwa, Hiroki Mori, Koji Shimatani, Haruta Mogami, Yukuo Konishi, and Toshio Tsuji
    Scientific Reports, volume 10, Article number: 11266, doi:10.1038/s41598-020-67855-0, Published online: 09 July 2020. (SCI, IF=4.011)
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    Spatiotemporal Parameterization of Human Reaching Movements Based on Time Base Generator

    Masanobu Kittaka, Akira Furui, Hiroto Sakai, Pietro Morasso, and Toshio Tsuji
    IEEE Access, vol. 8, pp.104944-104955, Digital Object Identifier: 10.1109/ACCESS.2020.3000273, Date of publication: 05 June 2020 (SCI, IF=4.098)
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    Non-invasive Central Venous Pressure Measurement Using Enclosed-zone Central Venous Pressure (ezCVPTM)

    Takayuki Hidaka, Yoji Sumimoto, Yoshihiro Dohi, Haruka Morimoto, Hitoshi Susawa, Kazuhiro Nitta, Ken Ishibashi, Satoru Kurisu, Haruki Hashimoto, Yukihiro Fukuda, Shogo Matsui, Shinji Kishimoto, Masato Kajikawa, Tatsuya Maruhashi, Teiji Ukawa, Chikara Goto, Ayumu Nakashima, Kensuke Noma, Toshio Tsuji, Yasuki Kihara, and Yukihito Higashi
    Circulation Journal, Vol.84, No.7, pp. 1112 – 1117, June 2020. (SCI, IF=3.025)

    The right hemisphere is important for driving-related cognitive function after stroke

    Koji Shimonaga, Seiji Hama, Toshio Tsuji, Kazumasa Yoshimura, Shinya Nishino, Akiko Yanagawa, Zu Soh, Toshinori Matsushige, Tatsuya Mizoue, Keiichi Onoda, Hidehisa Yamashita, Shigeto Yamawaki, and Kaoru Kurisu
    Neurosurgical Review, doi.org/10.1007/s10143-020-01272-911, March 2020 (SCI, IF=2.532)
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    Representative papers

    Human Hand Impedance Characteristics during Maintained Posture in Multi-Joint Arm Movements

    T. Tsuji, P. Morasso, K. Goto, and K. Ito
    Biological Cybernetics, Vol.72, pp.475-485, 1995.

    A Log-Linearized Gaussian Mixture Network and Its Application to EEG Pattern Classification

    T. Tsuji, O. Fukuda, H. Ichinobe, and M. Kaneko
    IEEE Transactions on Systems, Man, and Cybernetics-Part C: Applications and Reviews, Vol. 29, No. 1, pp. 60-72, February 1999.

    A Recurrent Log-linearized Gaussian Mixture Network

    T. Tsuji, N. Bu, M. Kaneko, and O. Fukuda
    IEEE Transactions on Neural Networks, Vol.14, No.2, pp.304-316, March 2003.

    A Human-Assisting Manipulator Teleoperated by EMG Signals and Arm Motions

    O. Fukuda, T. Tsuji, M. Kaneko and A. Otsuka
    IEEE Transactions on Robotics and Automation, Vol.19, No.2, pp.210-222, April 2003.

    Quantitative Evaluation of Pain during Electrocutaneous Stimulation using a Log-Linearized Peripheral Arterial Viscoelastic Model

    H. Matsubara, H. Hirano, H. Hirano, Z. Soh, R. Nakamura, N. Saeki, M. Kawamoto, M. Yoshizumi, A. Yoshino, T. Sasaoka, S. Yamawaki, and T. Tsuji
    Scientific Reports, volume 8, Article number: 3091, doi:10.1038/s41598-018-21223-11, Published online: 15 February 2018.

    Continuous Blood Viscosity Monitoring System for Cardiopulmonary Bypass Applications

    S. Okahara, Z. Soh, S. Miyamoto, H. Takahashi, S. Takahashi, T. Sueda, and T. Tsuji
    IEEE Transactions on Biomedical Engineering, Vol.64, No.7, pp. 1503-1512, DOI:10.1109/TBME.2016.2610968, JULY 2017.

    Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation

    H. Hirano, R. Takama, R. Matsumoto, H. Tanaka, H. Hirano, Z. Soh, T. Ukawa, T. Takayanagi, H. Morimoto, R. Nakamura, N. Saeki, H. Hashimoto, S. Matsui, S. Kishimoto, N. Oda, M. Kajikawa, T. Maruhashi, M. Kawamoto, M. Yoshizumi, Y. Higashi, and T. Tsuji
    Scientific Reports, volume 8, Article number: 9263, doi:10.1038/s41598-018-27392-3, Published online: 18 June 2018.

    A computational model of internal representations of chemical gradients in environments for chemotaxis of Caenorhabditis elegans

    Z. Soh, K. Sakamoto , M. Suzuki , Y. Iino, and T. Tsuji
    Scientific Reports, volume 8, Article number: 17190, doi:10.1038/s41598-018-35157-1, Published online: 21 November 2018.

    A Scale Mixture-based Stochastic Model of Surface EMG Signals with Variable Variances

    A. Furui, H. Hayashi, and T. Tsuji
    IEEE Transactions on Biomedical Engineering, DOI: 10.1109/TBME.2019.2895683, Date of Publication: 28 January 2019.

    A myoelectric prosthetic hand with muscle synergy-based motion determination and impedance model-based biomimetic control

    A. Furui, S. Eto, K. Nakagaki, K. Shimada, G. Nakamura, A. Masuda, T. Chin, and T. Tsuji
    Science Robotics, Vol. 4, Issue 31, eaaw6339, DOI: 10.1126/scirobotics.eaaw6339, 26 June 2019.

    Markerless Measurement and Evaluation of General Movements in Infants

    T. Tsuji, S. Nakashima, H. Hayashi, Z. Soh, A. Furui, T. Shibanoki, K. Shima, and K. Shimatani
    Scientific Reports, volume 10, Article number: 1422, doi:10.1038/s41598-020-57580-z, Published online: 29 January 2020.